I use the MiCasaverde Vera and they have a Radio RA2 plugin (I gave them remote access to my system so they could develop it). I can use the Vera to turn on/off dim, shades up, shades down, I have two separate 6 button keypads. Both have an engraved button for "stereo" which does not have a Lutron load programmed to it. When I press this button, Vera sees it and turns the Sonos on.
I can of course have Vera check the weather and turn the lights on. If certain doors are opened when certain (non-monitored) alarm sensors are "armed" (armed in Vera) then the Radio RA2 security feature kicks in and lights flash etc.
All this is great. I can even use my Amazon echo to send a command to a "hue clone server" running on raspberry pi that delivers URLs to Vera to control lights... (talk about multi-stage integration! Voice --> Echo --> Raspberry Pi --> Vera --> Lutron repeater)
But I don't know how much longer I can last with the Vera system.
What are other 3rd party systems folks are using reliably with Radio RA2?
I may make the move to OpenHab but there does not seem to be a Lutron Radio RA2 binding for it yet and not sure I have the skills to write one.